The Impact of Citrus Bergamot Extract on Hemato- Biochemical, Inflammatory and Oxidative stress Parameters Induced by Acute Amikacin Toxicity in male Albino Rats


 One of the most efficient aminoglycoside is amikacin. Yet, it has been linked to unwanted renal toxicity, which resulted in negative alterations various biochemical indicators, particularly those related oxidative stress, kidney function, and inflammation. The goal this research was see how citrus bergamot extract affected hemato-biochemical, inflammatory, stress parameters male rats triggered by acute amikacin toxicity.A total 30 were divided into five equal groups, each with six rats. first group received 1 ml DW orally its represent control group. Group given I.P. AK (1.2 gm/kg) on day seven. 2 100 mg/kg CBE for ten days. Groups (3) (4) 200 CBE, respectively, On seventh experiments, test groups. At end trial, blood samples used assess inflammatory markers, some hemato-biochemical parameters.Significantly higher levels serum MDA, IL-6, urea, creatinine, an adversely affect lipid profile, are indications AK-induced nephrotoxicity. Supplementation attenuated change these biomarkers.It concluded that supplementation protects against nephrotoxic effects because antioxidant, anti-inflammatory, hypolipemic properties.